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Pharmacotherapy for obesity


Obesity is a serious, chronic, relapsing disease of energy regulation, with strong genetic and early-life environmental determinants.

Medications can be useful adjunct to lifestyle intervention in effecting and maintaining clinically significant weight loss in those with BMI >30, or 27-30 and obesity-related complications.

*Check BMI here.

Safety and efficacy should be monitored closely on commencement and the medication should be discontinued if there are safety or tolerability issues, or if <5% weight loss is observed after 3-4 months

For the majority of patients, following the exemplary diet and exercise recommendation provide only modest or no weight loss and difficulty to sustain.


DrugStarting doseAvailable dosesWeight loss vs placebo (% or kg)Side EffectsContraindications
Phentermine15 mg15, 30, 40 mg3.6-4.5 kg in 6 monthsInsomnia, dry mouth, agitation, tachicardiaHypertension, glaucoma, history drug/alcohol abuse, SSRI antidepressants, pregnancy, heart disease
Orlistat120 mg TDS120 mg2.9-3.4% in 1 yearSteatorrhea, oil spotting, flatulence, incontinence, vitamin malabsorptionpregnancy
Liraglutide0.6 mg0.6 – 35.4% in 1 yearNausea, Rare pancreatitis, cholecystitisRenal/hepatic insufficiency, pregnancy, psychiatric disorder, past pancreatitis
Naltrexone/Bupropion8/90 mg4.8% in 1 yearNausea, headache, dizzy and dry mouthAntidepressants,
Topiramate12.5 mg mane25, 50, 100 mg3.4-5 kgInsomnia, dry mouth, paraesthesia, altered taste, dizziness, depressionGlaucoma, renal stones, pregnancyOff label
Phentermine/topiramate15 mg/12.5 mg mane15/12.5- 100 mg5-6.6% in 1 yearAs aboveAs aboveOff label
Metformin500 mg500-2000 mg0.6-1.2 kgBloating, diarrhea, Vit B12 deficiency, hypoglycemiaRenal problemsOff label
SGLT-2 (dapagliflozin, canagliflozin, empagliflozin)1.8 – 2.7 kgGenital and urinary tract infectionsRenal problemsOff label
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Email: me@vistaclinic.com.au

Phone: + 61 (0) 434 780 777 

Fax: +61 (03) 9978 9484

Business Hours:  By appointment. Monday, Tuesday, Thursday, Friday, Saturday. 

Flexible hours, including Sundays and holidays - for VIP.

Address: Suit 415, Level 4,

The Exchange Tower

530 Little Collins St  Melbourne 3000 VIC Australia

Main Entrance to the Exchange Tower from the Little Collins St or via coffee shops lane, then via lifts - to level 4.

* Melbourne architects have sense of humor! - 530 Collins and 530 Little Collins are across the road - you need a Little Collins one with the sign "The exchange Tower"

Chocolates/spring water and comfortable chairs on a waiting area.

We are flexible with hours for our regular loyal patients - please, contact reception or book appointment while at the practice.

Looking forward to see you!